Dealing with a terrible underwear sore right now. You know the kind you get from riding right where your leg attaches to your body, right where the hem/seam of your underwear is, right where there is a tendon or something that causes you to get those pressure sores or whatever they are. The sores look. 11 Feb Without underwear, you don't have any protection between the outer layer of your skin and the “harsh reality of the fabric and seams of your pants,” says Mona Gohara, M.D., an associate clinical professor of dermatology at Yale University. Related: 6 Ways to Prevent Chafing. This can cause painful skin. 24 Mar If you like to switch up your fabrics, she still recommends choosing underwear that has a cotton gusset (the part that's against your genitals). "Cotton allows for But as long as it's not accompanied by a foul odor, itching, bleeding, or pain, it is not necessarily a sign of trouble," says Nicoll. OK, so washing.